![]() In this regard, certain foods with antioxidant and anti-inflammatory effects have been shown to help protect against the negative effects of aging. Increased intake of antioxidants and anti-inflammatory compounds are believed to protect against this decline. This makes the brain more susceptible to the deleterious effects of OS and inflammation. While OS and inflammation both increase with age, the body’s ability to defend and repair itself decreases through the lifespan. Oxidative stress (OS) and inflammation in the brain contribute to the decline of motor abilities and cognitive performance with age. Therefore, tart cherries (like other dark-colored fruits), may be effective in reducing inflammatory and OS-mediated signals. Higher concentrations of tart cherry powder and longer exposure times negatively affected cell viability. Pretreatment with tart cherry decreased levels of NO, TNF-α, and COX-2 in a dose- and time-dependent manner versus those without pretreatment the optimal combination was between 0.125 and 0.25 mg/mL tart cherry for 2 h. LPS application increased extracellular levels of NO and tumor necrosis factor-alpha (TNF-α), and intracellular levels of iNOS and cyclooxygenase-2 (COX-2). Cells were pretreated with different concentrations (0–1.0 mg/mL) of Montmorency tart cherry powder for 1–4 h, then treated with 0 or 100 ng/mL lipopolysaccharide (LPS) overnight. Thus, the present study sought to determine if tart cherries-which improved cognitive behavior in aged rats-would be efficacious in reducing inflammatory and OS signaling in HAPI rat microglial cells. ![]() Previous studies have shown that polyphenols from dark-colored fruits can reduce stress-mediated signaling in BV-2 mouse microglial cells, leading to decreases in nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression. ![]() Depending on the harvest ( which depends on the weather, frost, heat, etc.), there may be deviations in color, taste and density.Tart cherries contain an array of polyphenols that can decrease inflammation and oxidative stress (OS), which contribute to cognitive declines seen in aging populations. Cherry PLUS is a 100% natural product, without preservatives or other additives. The recommended daily dose should not be exceeded. Note: Dietary supplements are not intended as a substitute for a varied, balanced diet and a healthy lifestyle. Storage: Store in a cool, dry place protected from light and out of the reach of small children. Montmorency tart cherry powder, guar gum, sunflower lecithin, cellulose (capsule shell) For the best results, take the Cherry PLUS capsules in the morning and Cherry PLUS concentrate in the evening. When taking the product for the first time, we recommend a minimum 12 week period of use. Recommended intake: Take 2 capsules daily with still water, if necessary stir the powder into water. Manufactured in Germany in pharmaceutical qualityĬomplete utilization of the entire cherry except the stone and stemĬontent: 1100 mg Montmorency tart cherry powder per daily dose (2 capsules). Particularly high antioxidants and anthocyanin content Gluten- and lactose-free as well as free of synthetic additives, artificial vitamins or chemical additives Due to the high-quality production and the highest quality standards, it is among the best-selling cherry products in Europe since many years.Įxcellent for diabetics (2 capsules = 0.04 BU per day)Įxtraction through gentle freeze-drying process Montmorency Tart Cherry Capsules – Cherry PLUSĬherry PLUS® brand is the leading and most concentrated tart cherry powder (ratio 50:1) in Germany’s pharmacies.
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